Accession Number : AD1048115


Title :   Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins


Descriptive Note : Technical Report,15 Aug 2013,14 Jul 2017


Corporate Author : The University of British Columbia Vancouver, BC Canada


Personal Author(s) : Daugaard, Mads


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1048115.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 87


Abstract : In this project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSAinterferes with key functions of the cancer cell like growth, migration and invasion. We have furthermore made proof-of-concept that a VAR2CSA protein conjugated with a toxin(hemiasterlin) efficiently eradicates breast cancer bone metastasis in a syngeneic mouse model. As such, all aims in this project has been fulfilled.


Descriptors :   breast cancer , tumor cell line , tissues (biology) , RECOMBINANT PROTEINS , targeting , metastasis , IMMUNOCHEMISTRY , mutations , stem cells


Subject Categories : Medicine and Medical Research
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE