Accession Number : AD1047997


Title :   Acute Pancreatitis as a Model to Predict Transition of Systemic Inflammation to Organ Failure in Trauma and Critical Illness


Descriptive Note : Technical Report,22 Sep 2016,21 Sep 2017


Corporate Author : The University of Pittsburgh Pittsburgh United States


Personal Author(s) : Whitcomb, David C ; Wilson,Annette S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047997.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 19


Abstract : Trauma, extensive burns, bacterial infections, and acute pancreatitis (AP) are common conditions of tissue injury and immune system activation that can result in the systemic inflammatory response syndrome (SIRS). Surprisingly, about half of the patients with SIRS quickly recover, while the others develop a multiorgan dysfunction syndrome (MODS). SIRS and MODS do not occur immediately: SIRS evolves over a 4-12 hour period, while MODS evolves over12-24 hours. Vascular leak syndrome (VLS) is a critical component of the transition from SIRS to MODS. Understanding the mechanism by which SIRS triggers VLS and progresses to MODS is critical to correctly model disease course thereby aiding in treatment of patients. In this report, we analyzed the serum samples for proteins and fatty acids that will help to understand a mechanism for cytotoxicity to endothelial cells. The results demonstrate elevated cytokine, Ang-1, Ang-2 and activin levels in serum samples from patients with severe AP. Also, initial mass spectrometry findings show potential biomarkers that will be explored.


Descriptors :   pancreas , inflammation , biological markers , endothelium , VIABILITY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE