Accession Number : AD1047900

Title :   Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury

Descriptive Note : Technical Report,15 Aug 2012,14 Aug 2015

Corporate Author : University of Tennessee Health Science Center Memphis United States

Personal Author(s) : Morales-Tirado, Vanessa M

Full Text :

Report Date : 01 Feb 2018

Pagination or Media Count : 26

Abstract : In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.

Descriptors :   inflammation , apoptosis , blast injuries , cells (biology) , trauma , physiological effects , retina , pathophysiology , brain , GLAUCOMA

Subject Categories : Medicine and Medical Research
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE