Accession Number : AD1047900


Title :   Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury


Descriptive Note : Technical Report,15 Aug 2012,14 Aug 2015


Corporate Author : University of Tennessee Health Science Center Memphis United States


Personal Author(s) : Morales-Tirado, Vanessa M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047900.pdf


Report Date : 01 Feb 2018


Pagination or Media Count : 26


Abstract : In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.


Descriptors :   inflammation , apoptosis , blast injuries , cells (biology) , trauma , physiological effects , retina , pathophysiology , brain , GLAUCOMA


Subject Categories : Medicine and Medical Research
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE