Accession Number : AD1047663


Title :   CXCL14 Blockade of CXCL12/CXCR4 Signaling in Prostate Cancer Bone Metastasis


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Regents of the University of Michigan Ann Arbor United States


Personal Author(s) : Clines, Gregory A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047663.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 57


Abstract : Bone metastasis is a common and unfortunate complication of advanced prostate cancer resulting in significant pain and fractures. The most devastating consequence, however, is that once the cancer has metastasized to bone, the disease is incurable. Up to 90 percent of men who succumb to prostate cancer have bone metastasis, which demonstrates the strong attraction of prostate cancer to bone. Chemokines are essential in cancer progression and metastasis. The chemokine CXCL14 was identified in a screen for factors that support prostate cancer bone metastasis. In a human prostate cancer tissue microarray, CXCL14 expression was found significantly greater in prostate cancer metastasis to bone compared to metastasis to other organs, suggesting that this chemokine has important effects that are specific to bone. The goal of this proposal is to understand the role of CXCL14 in the homing and progression of prostate cancer to bone.


Descriptors :   PROSTATE CANCER , metastasis


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE