Accession Number : AD1047654


Title :   IL-9-Producing Mast Cell Precursors and Food Allergy


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Childrens Hospital Medical Center Cincinnati United States


Personal Author(s) : Wang,Yui H ; Hogan,Simon P ; Tomar,Sunil ; Shik,Dana ; Smith,Andrew


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047654.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 22


Abstract : Food allergy is a harmful immune reaction driven by uncontrolled type-2 immune responses. Current knowledge provide limited insights into why only some, rather than all food allergic individuals are prone to develop life-threatening anaphylaxis. We have identified a novel multi-functional IL-9-producing mucosal mast cells (MMC9s) that produce large amounts of IL-9, IL-13, and mast cell mediators. The objective of this proposal is to identify the factors that regulate MMC9 induction, which represents the key cellular checkpoint to develop food-induced anaphylaxis. The central hypothesis is that signals induced by IL-4 and antigen/IgE/FcRcomplex crosslinking act together to induce mast cell (MC) progenitors to develop into the pathogenic MMC9s, which amplify anaphylactic response to dietary allergens. We have established genetically modified murine strains, a new reconstitution model of experimental food allergy, and the system to acquire duodenal biopsy samples from food allergic patients. Preliminary evidences show that both IL-4 and antigen/IgE/FcRI complex are essential for MMC9 development. The findings provide a plausible view that the combinatorial signals from atopic status and dietary allergen ingestions can induce aberrant MMC9 development, resulting in the susceptibility to life-threatening anaphylaxis. The impact from these studies may facilitate the discovery of biomarkers and therapeutic targets for diagnosing, preventing, and treating food allergy.


Descriptors :   ALLERGY AND IMMUNOLOGY , response , food , patients , ANAPHYLAXIS , HYPERSENSITIVITY , therapeutics , GENETIC MARKERS , immune system , EXPOSURE (PHYSIOLOGY) , SIGNS AND SYMPTOMS , allergens


Subject Categories : Food, Food Service and Nutrition
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE