Accession Number : AD1047631


Title :   Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Albert Einstein College of Medicine Bronx United States


Personal Author(s) : Ostrer,Harry ; Rosenstein,Barry S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047631.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 16


Abstract : From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms (SNPs) meet the stringent threshold for genome-wide significance (meta-p-value 5x10-8), and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all studies for which data were available.


Descriptors :   prostate cancer , RADIOTHERAPY , patients , neoplasms , tissues , organs(anatomy) , RADIATION DOSAGE , medical research , clinical trials


Subject Categories : Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE