Accession Number : AD1047622


Title :   Joint Distraction Treatments of Intra-Articular Fracture-Induced Posttraumatic Osteoarthritis in a Large Animal Model


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : The University of Iowa Iowa City United States


Personal Author(s) : Goetz, Jessica E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047622.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 28


Abstract : Post-traumatic osteoarthritis (PTOA) is a common complication after an intra-articular fracture (IAF) in both combat and civilian settings. The broad goal of this expansion award is to determine if joint distraction can prevent the development of PTOA after an IAF. During this second project year we continued analysis of the specimens generated during Project Year 1, developing and implementing new routines for confocal microscopy image analysis, contrast-enhanced micro CT analysis, and kinematic analysis. We also performed Western blots to analyze the synovial fluid harvested from the experimental joints. Results from this work corroborate our macroscopic finding that delays in fracture fixation do have a negative effect on cartilage, and immediate joint distraction did not have a therapeutic benefit. Our research team suffered a personal and professional loss with the death of our histologist which significantly delayed final histological analysis specimens from this first series. During this second project year we also completed all surgeries on the remaining animals in Specific Aim 1. Groups comparing immediate and delayed fracture fixation were completed in the spring and the remaining distracted group just prior to the end of the Project Year. Joint distraction was performed through the articulated distraction device that was developed this Year for use in the upcoming Aim 2 studies.


Descriptors :   arthritis , BONE FRACTURES , JOINTS (ANATOMY) , wounds and injuries , combat operations , military personnel , civilian population , therapeutics , surgery , ankle , cartilage , histology , inflammation


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE