Accession Number : AD1047605


Title :   Treatment-Induced Autophagy Associated with Tumor Dormancy and Relapse


Descriptive Note : Technical Report,01 Jul 2016,30 Jun 2017


Corporate Author : Virginia Commonwealth University Richmond United States


Personal Author(s) : Gewirtz, David A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047605.pdf


Report Date : 01 Jul 2017


Pagination or Media Count : 77


Abstract : Despite advances in cancer therapeutics over recent decades, developing effective strategies for the treatment of triple negative breast cancer (TNBC) continues to represent a significant challenge. Cytotoxic chemotherapies that often include doxorubicin (Adriamycin) remain the standard of care in breast cancer; while generally successful, patients frequently relapse with therapy resistant disease. Immunotherapy has emerged as a treatment modality with great promise, but has seen limited success in breast cancer therapy due, in large part,to the low immunogenicity of breast cancer cells. In view of the fact that doxorubicin has been shown to improve tumor immunogenicity by promoting the secretion of damage-associated molecular pattern (DAMP) molecules and immunogenic cell death (ICD), our recent goals were to enhance sensitivity to chemotherapy by both cell autonomous and cell non-autonomous strategies.


Descriptors :   breast cancer , immunotherapy , chemotherapy , TUMOR CELL LINE


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE