Accession Number : AD1047545


Title :   Adult Stem Cell-Based Enhancement of Nerve Conduit for Peripheral Nerve Repair


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : University of Pittsburgh Pittsburgh United States


Personal Author(s) : Tuan,Rocky S ; Alexander,Peter


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047545.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 29


Abstract : Musculoskeletal trauma is frequently accompanied by injuries to peripheral nerves; if not repaired, the trauma can lead to significant dysfunction and disability. While nerves have the ability to regenerate and to reconnect across a limited gap, surgical intervention is often required to assist them in bridging a larger gap. Typically, surgeons will transplant a less important nerve from elsewhere in the body to the site of injury to provide a patch for the injured nerve. However, acceptable donor nerves are often not available for this purpose, particularly in patients suffering multiple extremity injuries or faced with traumatic amputations. Alternatives include the use of a blood vessel graft or a synthetic nerve guide, although these devices are only effective over distances less than 3 cm, mainly because of their lack of appropriate nerve-enhancing biological activities. In our current work, we have identified and isolated stem cells from the injured tissue site that have wound healing promoting activities. In this application, we propose to use these cells, which may be obtained autologously from the patient, in conjunction with a biodegradable scaffold tube to form bioactive nerve conduits that may be grafted to provide better guidance for the microstructure of the nerve to bridge the injury gap.


Descriptors :   MUSCULOSKELETAL SYSTEM , trauma , wounds and injuries , nerves , PERIPHERAL NERVOUS SYSTEM , stem cells , nanofibers , TISSUE ENGINEERING


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE