Accession Number : AD1047495


Title :   Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Johns Hopkins University Baltimore United States


Personal Author(s) : Mowry,Ellen ; Newsome,Scott ; Avornu,Ama


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047495.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 8


Abstract : Cognitive dysfunction is common and devastating to people with multiple sclerosis (MS). To date, multiple pharmacologic interventions have been tried for MS-related cognitive dysfunction with disappointing results. Hence, there is an urgent need to identify or develop novel therapies that can help improve cognitive function in MS. This clinical trial is designed to evaluate the safety, tolerability, and efficacy of intranasal insulin in cognitively impaired people with MS. The study will also evaluate the impact of intranasal insulin on measures of oxidative stress, axonal injury, cellular stress, and energy metabolism in MS. The design of this phase I/II, randomized, double-blind, placebo-controlled trial is as follows; 105participants will be randomized (1:1:1, stratified by relapsing versus progressive MS) to intranasal insulin 10 international units (IU) twice a day, 20 IU twice a day, or placebo for 24weeks. Insulin will be administered intranasally to allow direct delivery of the medication into the central nervous system.


Descriptors :   MULTIPLE SCLEROSIS , Cognitive Impairment , NEURODEGENERATIVE DISEASES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE