Accession Number : AD1047396


Title :   Biological Effects of Ionising Radiation and Countermeasures (Les effets biologiques des rayonnements ionisants et leurs contre-mesures)


Descriptive Note : Technical Report


Corporate Author : NATO SCIENCE AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE) NEUILLY-SUR-SEINE France


Personal Author(s) : Herodin,Francis


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047396.pdf


Report Date : 01 Jan 2018


Pagination or Media Count : 244


Abstract : The HFM-222 RTG (active 2012 2016) addressed the medical challenges of NATO military defensive operations that could be conducted in a nuclear/radiological (NR) environment. The HFM-222 Technical Report deals with high level and low level radiation issues through the following cross-cutting themes: i) biomarkers of exposure and effects; ii) early and late effects; iii) medical countermeasures; iv) modelling; v) guidance. Several deliverables taking into account military medical relevant research and operational needs were accomplished such as seventy peer reviewed publications and one exercise dealing with radiological triage/diagnosis based on clinical dosimetry following a first biological dosimetry exercise implemented in 2011. The RTG produced different mature and deployable software tools dealing with the assessment triage (i.e., Mobile-FRAT, which is an Android and IOS based application) or the evaluation of Radiation Induced Performance Decrement (RIPD) and Health Effects from Nuclear and Radiological Environments (HENRE) which integrate complex exposure scenarios. Biomarkers of effect and damage were developed in order to diagnose and predict the clinical outcome of irradiated victims. Regarding treatment strategies, the RTG contributed to the FDA approval of granulocyte colony-stimulating factor (filgrastim) to mitigate radiation-induced neutropenia in NR accident victims. For high dose localized exposures adipose tissue-derived stem cells represent a promising cell drug to mitigate cutaneous radiation syndrome. Moreover, as low dose NR events may disrupt military operations, relevant models were developed to address related medical issues and retrospective epidemiological studies were conducted.


Descriptors :   RADIOLOGICAL WARFARE , RADIOLOGIC HEALTH , RADIOLOGICAL WEAPONS , radioLOGICAL WARFARE AGENTS , IONIZING RADIATION , DOSIMETRY , Biomarkers


Subject Categories : Chemical, Biological and Radiological Warfare
      Radioactiv, Radioactive Wastes & Fission Prod


Distribution Statement : APPROVED FOR PUBLIC RELEASE