Accession Number : AD1047189


Title :   Targeting Sulfotransferase (SULT) 2B1b as a regulator of Cholesterol Metabolism in Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Purdue University West Lafayette United States


Personal Author(s) : Ratliff,Timothy


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047189.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 23


Abstract : Abundant epidemiological and experimental evidence establishes alterations in cholesterol metabolism as a key driver of prostate cancer (PCa) aggressiveness. Our preliminary data shows cholesterol sulfotransferase (SULT) 2B1b, a global regulator of cholesterol metabolism, is overexpressed in human prostate neoplasia and PCa cell lines and that genetic knock down suppresses LNCaP growth and diminishes androgen receptor (AR) activity. It is hypothesized that SULT2B1b modulates PCa growth and phenotype via alterations in cholesterol metabolism. If validated, the studies will form the foundation for novel therapeutic intervention.


Descriptors :   PROSTATE CANCER , CHOLESTEROL , Metabolism , THERAPY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE