Accession Number : AD1047141


Title :   Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Northern California Institute for Research and Education San Francisco United States


Personal Author(s) : Yaffe, Kristine


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047141.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 9


Abstract : The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment (CI) in veterans and compare it to that of veterans with Alzheimer's Disease (AD) and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from AD and normal aging. Specifically, we hypothesize that: 1) patients with TBI associated CI will have higher phospho-tau/total tau ratio than controls who have not had a TBI, and that 2) TBI-associated CI will be associated with elevations in inflammatory markers compared to controls and 3) a decrease in b-amyloid measures compared to controls but not as low as in the setting of AD. We recently completed enrollment. Data from 160 participants has been collected (66 TBI, 54 controls, and 40 with AD and no TBI). Now that data collection is complete, we will examine the biomarker profile of the groups. This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.


Descriptors :   trauma , brain injuries , dementia , chronic encephalopathy , biological markers , biological aging , Alzheimer disease , cognitive impairment , veterans (military personnel)


Subject Categories : Medicine and Medical Research
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE