Accession Number : AD1047106

Title :   Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis

Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author : Tel Aviv University Tel Aviv Israel

Personal Author(s) : Goldstein , Itamar ; Kloog,Yoel ; Zayoud,Morad ; Sfadia,Galit E ; Moshe,Itzhak B ; Vax,Einav ; Ben Moshe,Itzhak

Full Text :

Report Date : 01 Oct 2016

Pagination or Media Count : 37

Abstract : During the first two year of the award, we made several high impact key observations:(I) Prophylactic treatment with Farnesylthiosalicylic acid (FTS), a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis (AIA) model by all outcome parameters(Clinical assessment and relevant laboratory/immunological/Molecular analyses). (II) Prophylactic dosing of FTS combined with methotrexate (MTX) provides a synergistic protective effect (90 disease inhibition).(III) The FTS derivative, F-FTS, showed superior therapeutic clinical efficacy compared to FTS in the AIA model.

Descriptors :   arthritis , IMMUNOMODULATION , inhibitors , cells (biology) , inflammation , ANGIOTENSIN

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE