Accession Number : AD1047106


Title :   Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Tel Aviv University Tel Aviv Israel


Personal Author(s) : Goldstein , Itamar ; Kloog,Yoel ; Zayoud,Morad ; Sfadia,Galit E ; Moshe,Itzhak B ; Vax,Einav ; Ben Moshe,Itzhak


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1047106.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 37


Abstract : During the first two year of the award, we made several high impact key observations:(I) Prophylactic treatment with Farnesylthiosalicylic acid (FTS), a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis (AIA) model by all outcome parameters(Clinical assessment and relevant laboratory/immunological/Molecular analyses). (II) Prophylactic dosing of FTS combined with methotrexate (MTX) provides a synergistic protective effect (90 disease inhibition).(III) The FTS derivative, F-FTS, showed superior therapeutic clinical efficacy compared to FTS in the AIA model.


Descriptors :   arthritis , IMMUNOMODULATION , inhibitors , cells (biology) , inflammation , ANGIOTENSIN


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE