Accession Number : AD1046770


Title :   Development of a Blood-Based Biomarker Panel for Indeterminate Lung Nodules


Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016


Corporate Author : University of Texas MD Anderson Cancer Center Houston United States


Personal Author(s) : Taguchi,Ayumu


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046770.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 8


Abstract : Lung cancer screening with low-dose CT (LDCT) has been shown to reduce mortality by 20 , although there are concerns including high false positivity, cost, and radiation exposure. Blood-based markers are a promising and attractive approach to complement LDCT because of the potential to identify those subjects that need to undergo further work-up for their indeterminate nodules. The main objective of my proposed project is to develop a blood-based biomarker panel from three platforms (protein, autoantibody and microRNA) to distinguish malignant lung nodules from benign lung nodules. We have so far assayed 20 protein markers, 122 autoantibodies, 20 microRNAs, and a metabolite DAS, in the 149 malignant lung nodules and 187 benign lung nodules.


Descriptors :   lung cancer , cancer research , biological markers , validation , DIAGNOSTIC IMAGING


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE