Accession Number : AD1046699


Title :   Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Brigham and Women's Hospital Boston United States


Personal Author(s) : Poole,Elizabeth


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046699.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 8


Abstract : Mouse models suggest that chronic stress promotes ovarian tumorigenesis, but the relationship between stress and ovarian cancer has never been evaluated in humans. Over the last year of the grant, we published an analysis demonstrating that exposure to chronic stress leads to tumors that express the beta-2 adrenergic receptor, the signaling pathway identified in mouse models. We have also made progress developing a metabolomic signature of post-traumatic stress disorder (PTSD), a sentinel chronic stress condition. Overall, our continuing work on the role of stress in ovarian cancer development indicates that chronic stress may increase risk of developing ovarian cancer.


Descriptors :   ovarian cancer , STRESS(PSYCHOLOGICAL) , neoplasms , metabolomics , depression , anxiety


Subject Categories : Medicine and Medical Research
      Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE