Accession Number : AD1046530


Title :   Low Cost, High-Throughput 3-D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Vanderbilt University Medical Center Nashville United States


Personal Author(s) : Chekmenev, Eduard Y


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046530.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 196


Abstract : According to the original statement of work we have focused our activities on three specific aims. With regards to Aim number 1, we have been working on the construction of (129)Xe automated hyperpolarizer and began device testing; The remaining efforts (for Year 3) will be focused on device construction complete, automation and optimization, and integrated use with the MRI scanner. With regards to Aim number 2, we have focused a considerable amount of the effort on investigating the fundamental parameters of propane hyperpolarization and lifetimes in the gas and phase. In particular, we have studied the pressure dependence of the propane lifetimes at low magnetic fields, and we have identified the limits of the magnetic field for hyperpolarized propane technology (is similar to 0.4 T). These and Year 1 discoveries guided our efforts for the overall propane hyperpolarizer design. The prototype (which will likely remain the final design) is completed, and we are now waiting automation component for device automation. Regarding aim number 3, we have worked with equipment vendors and finalized the design of the low-field MRI scanner (by using a new commercial vendor). See report for details. We also note that we are submitting a duplicating report for two partnering PI awards of the same project: W81XWH-15-1-0271 and W81XWH-15-1-0272.


Descriptors :   MAGNETIC RESONANCE IMAGING , lung , propane


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE