Accession Number : AD1046526


Title :   Combination Therapies for the Mitigation of Musculoskeletal Pathologic Damage in a Novel Model of Severe Injury and Disuse


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : University of Texas Southwesern Medical Center Dallas United States


Personal Author(s) : Wolf, Steven


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046526.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 34


Abstract : Severe injury in patients results in adverse physiologic and musculoskeletal changes that are immediate and long lasting. In response to injury, metabolic and physiologic responses determine length of hospitalization and subsequent activity limitations. Reduced mobility from bed rest and injury severity affect muscle and bone health and are detrimental to rehabilitative success. Therefore, means to counteract adverse effects on muscle and bone after injury and disuse are needed. Pharmacologic (i.e insulin or oxandrolone), non-pharmacologic (i.e. exercise) and nutritional interventions have been used independently with limited success [17]. The combination of pharmacological interventions and exercise has not been systematically investigated. We propose to determine if the administration of pharmacologic agents combined with exercise attenuates muscle atrophy and bone degradation following severe injury, disuse and re-ambulation. The current proposal is for mitigation of musculoskeletal pathologic change in polytrauma patients.


Descriptors :   THERAPY , RATS , BURNS , Exercise (Physiology) , Strength (Physiology) , Muscles , Bones , WOUNDS AND INJURIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE