Accession Number : AD1046482


Title :   Autologous Hematopoietic Stem Cell Transplantation to Prevent Antibody Mediated Rejection After Vascularized Composite Allotransplantation


Descriptive Note : Technical Report,15 Sep 2016,14 Sep 2017


Corporate Author : Johns Hopkins University Baltimore United States


Personal Author(s) : Brandacher, Gerald


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046482.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 12


Abstract : The investigators successfully performed initial control experiments in unsensitized animals applying the proposed induction and maintenance immunosuppressive regimen to assess its safety and feasibility for maintaining VCA allograft survival in this model. Successful VCA (i.e. swine heterotopic hind limb) transplantation was performed across a full SLA mismatch from a CC donor to an AD recipient animal. The animal was treated with non-myeloablative total body irradiation and thymic irradiation two days prior to transplantation and with continues calcineurin inhibitor-based immunosuppressive maintenance therapy using tacrolimus at target trough levels of 10-20 ng/ml for 30 days.


Descriptors :   transplants , rejection , IMMUNOSUPPRESSION , therapeutics


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE