Accession Number : AD1046207


Title :   The Role of Tissue-Resident Donor T Cells in Rejection of Clinical Face Transplants


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Brigham and Women's Hospital Boston United States


Personal Author(s) : Pomahac , Bohdan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046207.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 14


Abstract : Unlike solid organ transplants, face transplants have a unique immunological characteristic the presence of skin, which contains approximately 1 million T cell/cm2. A full face transplant is 600-700 cm2 in size and therefore, contains approximately 600-700 million donor T cells. The long-term persistence of donor T cells within facial allografts and the role of donor vs. recipient T cells in face transplant rejection are two critical issues that have never been studied. We plan to (i) quantify the number and diversity of donor vs. recipient T cells within face transplants over time using cutting edge high throughput TCR sequencing (HTS), (ii) identify pathogenic T cell clones implicated in rejection, (iii) identify if these pathogenic T cell clones are of donor vs. recipient, and (iv) determine if these pathogenic T cell clones are measurable in blood during episodes of rejection and could therefore serve as an earl and personalized biomarker of rejection.


Descriptors :   surgical transplantation , FACE (ANATOMY) , skin (anatomy) , T lymphocytes , biological markers , blood chemistry


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE