Accession Number : AD1046165


Title :   Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Trustees of the University of Pennsylvania Philadelphia United States


Personal Author(s) : Levine,Matthew H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046165.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 17


Abstract : This work proposes to investigate the impact of histone deacetylase (HDAC) drug inhibition or deletion on the tolerance of limb warm and cold ischemia reperfusion injury (IRI) in scenarios relevant to limb transplantation using mouse models for experimentation. Limitations in tolerated ischemia times limits the scope of donors that can be considered for any particular vascularized composite allotransplant (VCA) recipient. Mitigating IRI therapeutically would have significant impact on the applicability of VCA to military personnel suffering catastrophic limb or tissue loss.


Descriptors :   SURGICAL TRANSPLANTATION , inhibition , drug therapy


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE