Accession Number : AD1046111


Title :   Developing a PTEN-ERG Signature to Improve Molecular Risk Stratification in Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Johns Hopkins University Baltimore United States


Personal Author(s) : Marchionni , Luigi ; Lotan,Tamara L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046111.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 9


Abstract : Prostate cancer (PCA) is a clinically and genetically heterogeneous and the development of a molecular classification is critical to distinguish lethal from indolent tumors and minimize overtreatment. Genomic alterations of the PTEN and ERG genes are among the most common in PCA and there is an interest in exploiting these alterations for routine risk assessment. We found that PTEN loss is most strongly associated with PCA death in patients whose tumors do not carry an ERG gene rearrangement, suggesting that ERG absence strengthens PTEN loss association with lethal progression. Despite the widely accessible PTEN/ERG molecular classification, our understanding of their biological interaction along PCA progression remains very limited. Hence, in our study we will perform a comprehensive molecular profiling of well-annotated PCA samples in relation to PTEN and ERG status. Our goals are threefold: 1) to confirm that PTEN/ERG double negative tumors are the most aggressive; 2) to characterize the expression profiles associated with PTEN and ERG alterations; and 3) to determine whether such expression profiles can be used to improve PCA patient stratification into different risk groups.


Descriptors :   prostate cancer , gene expression , RNA SEQUENCE ANALYSIS , cell line


Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE