Accession Number : AD1046109


Title :   Developing a PTEN-ERG Signature to Improve Molecular Risk Stratification in Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : John Hopkins University Baltimore United States


Personal Author(s) : Lotan, Tamara


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046109.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 10


Abstract : Based on previous work and our own preliminary data, it is clear that there exist distinctive molecular correlates of PTEN loss in the context of ETS-negative versus ETS-positive human prostate cancers and that these may drive prognosis following PTEN loss. Ultimately, elucidation of the molecular underpinnings of PTEN-ERG crosstalk holds promise for clarifying the mechanisms underlying the aggressive behavior seen in ERG-negative/PTEN-negative tumors, and may enable rational design of more effective therapeutic strategies and prognosticators for this subset of patients. We propose to test two hypotheses generated by our preliminary data: 1) PTEN loss in the absence of ETS gene expression is associated with an increased proliferative rate and a significantly increased risk of metastasis and death; and 2) ETS expression interacts with PTEN loss to modulate the transcriptional output from key oncogenic transcription factors such as MYC. Here we report on the initial studies performed for this award.


Descriptors :   prostate cancer , gene expression , RNA SEQUENCE ANALYSIS


Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE