Accession Number : AD1046086


Title :   Peritransplant Treg-Based Immunomodulation to Improve VCA Outcomes


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Children's Hospital of Philadelphia Philadelphia United States


Personal Author(s) : Hancock, Wayne W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1046086.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 20


Abstract : We have undertaken studies of how Treg cells may be used to enhance outcomes in VCA recipients, using murine models of orthotopic limb transplantation. Using this model, we have shown that expansion of Tregs can be used to significantly prolong orthotopic limb allograft survival. In addition, we have shown that Treg infusion can be used to promote orthotopic VCA survival. These data are highly encouraging and are of translational significance. These studies are those proposed for Specific Aim 1, and Specific Aim 2 will be tackled in the coming year.


Descriptors :   SURGICAL TRANSPLANTATION , transplants , rejection , TOLERANCES (PHYSIOLOGY) , IMMUNOMODULATION , inhibitors , t lymphocytes


Subject Categories : Medicine and Medical Research
      Biochemistry
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE