Accession Number : AD1045677


Title :   Phase 2 Study of AZD2014, a Dual mTORC1/mTORC1 Inhibitor,for NF2 Patients with Progressive or Symptomatic Meningiomas


Descriptive Note : Technical Report,15 May 2016,14 May 2017


Corporate Author : Massachusetts General Hospital Boston United States


Personal Author(s) : Plotkin, Scott R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1045677.pdf


Report Date : 01 Jun 2017


Pagination or Media Count : 7


Abstract : Meningiomas are common in neurofibromatosis 2 (NF2) patients with a cumulative incidence of80 by 70 years of age. Meningiomas that progress despite surgery and radiation are an important unmet medical need for these patients. To date, no chemotherapy has demonstrated efficacy against NF2-related meningiomas. Our laboratory studies have shown that treatment of primary meningioma cells with AZD2014, a mTORC1/mTORC2 inhibitor, leads to decreased cell viability/proliferation. Thus, we hypothesize that AZD2014 will be effective in treating symptomatic or progressive meningiomas in NF2 patients.


Descriptors :   neoplasms , HEREDITARY DISEASES , therapeutics , inhibitors , drug therapy , clinical trials


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE