Accession Number : AD1045663


Title :   Prostate Specific Membrane Antigen (PSMA) Targeted Bio-orthogonal Therapy for Metastatic Prostate Cancer


Descriptive Note : Technical Report,15 Sep 2016,14 Sep 2017


Corporate Author : John Hopkins University Baltimore United States


Personal Author(s) : Artemov, Dmitri


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1045663.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 7


Abstract : During the first year of the project we have identified new monoclonal anti-PSMA antibody(mAb), which demonstrated high affinity to the PSMA receptor and excellent targeting of PSMA expressing prostate cancer cells both in vitro and in vivo. We investigated details of them Ab and therapeutic complexes internalization in these cells and demonstrated rapid perinuclear localization of internalized agents. We have also synthesized and tested click reactive components for in vivo therapy. First in vivo data for anti-PSMA click-based pretargeting have been obtained with NIR in vivo optical imaging. In addition, all regulatory reviews of the proposed animal procedures have been successfully completed.


Descriptors :   prostate cancer , biological markers , therapeutics , targets


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE