Accession Number : AD1045514


Title :   Curcumin Nanoparticle Therapy for Gulf War Illness


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : The Texas A and M University System College Station United States


Personal Author(s) : Shetty, Ashok K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1045514.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 13


Abstract : The major goal of this project is to examine the efficacy of oral administration of curcumin (CUR) encapsulated biodegradable polymer nanosystems (nCUR) for alleviating cognitive, memory and mood impairments in a rat model of gulf war illness(GWI). Specific Aim 1 studies involve quantification of the efficacy of oral administration of different doses of nCUR for improving neurogenesis and suppressing inflammation and oxidative stress in the hippocampus. Specific Aim 2 studies will examine whether an apt dose of nCUR treatment (based on Specific Aim 1 studies) is efficient for alleviating cognitive, memory and mood impairments in GWI-rats, when treatment is commenced at an extended time-point (8-months) after exposure to GWIR chemicals and stress. During the past year, a set of experiments related to Specific Aim 1 studies was performed: (1) Exposure of rats to GWI related chemicals and moderate stress.


Descriptors :   PERSIAN GULF SYNDROME , nanoparticles , drug therapy , inflammation , memory , stress (physiology) , cognition , memory , polymers , ANXIETY , Hippocampus , PYRIDOSTIGMINE BROMIDE


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE