Accession Number : AD1045207

Title :   Targeted Alteration of Dietary Omega-3 and Omega-6 Fatty Acids for the Treatment of Post-Traumatic Headaches

Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author : Henry M. Jackson Foundation for the Advancement of Military Medicine Inc Bethesda United States

Personal Author(s) : Kenney, Kimbra L

Full Text :

Report Date : 01 Oct 2016

Pagination or Media Count : 11

Abstract : Post-traumatic headache (PTH) is a common problem in military personnel due to their high rate of traumatic brain injury (TBI). From a prior study in migraine we demonstrated that a high Omega-3/low Omega-6 (H3-L6) diet intervention reduced headache pain, altered circulating anti- and pro-nociceptive lipid mediators and their precursor fatty acids, reduced psychological distress and improved quality-of-life in a chronic headache population. We propose to carry out a 2-arm, parallel group, randomized, controlled 12-week dietary intervention trial to evaluate the biochemical effects and therapeutic efficacy of two dietary interventions (one high in Omega-3 and the other high in Omega-6, reflecting the usual US diet) in patients with PTH that are migrainous. We hypothesize that compared to the Control Diet (high Omega-6, low Omega-3), the H3-L6 intervention will produce significant increases in anti-nociceptive n-3 metabolites including 17-hydroxy DHA (Primary Biochemical Aim), and reductions in pro-nociceptive n-6 metabolites. Further, we hypothesize that compared to the Control Diet, the H3-L6 intervention will produce significant improvement in the Headache Impact Test(a headache-specific quality of life measure-Primary Clinical Outcome), mean total Headache Hours per day, and mean Severe Headache Hours per day.

Descriptors :   HEADACHE DISORDERS , trauma , brain injuries , inflammation , biological markers , FATTY ACIDS , diet , military personnel , biochemistry

Subject Categories : Medicine and Medical Research
      Food, Food Service and Nutrition

Distribution Statement : APPROVED FOR PUBLIC RELEASE