Accession Number : AD1045152


Title :   Prevention of Organ Injury in Exertional Heat Stroke: Preclinical Evaluation of a New Class of NSAIDs


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : University of Florida Gainesville United States


Personal Author(s) : Clanton, Thomas L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1045152.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 54


Abstract : In the first year we have completed a study of 128 adult male and female mice. Each mouse was exercise trained for a period of 3 weeks and then exposed to exertional heat stroke (EHS), running on a forced running wheel in a 37.5 deg C/35% RHG environmental chamber. Mice ran until they became unconscious (core temperature of 42.2 deg C in both sexes), neurological symptoms and organ injury resembling human EHS. Blood and tissue samples were collected at 0.5 h, 3 h, 24 h 4d,9d and 14d of recovery. Heart tissue and plasma were submitted for metabolomic and lipidomic analysis (awaiting results). Blood samples were submitted for cytokine analyses, metabolic hormone analyses and corticosteroids. Female mice were significantly more resistant to EHS, running longer, at higher running velocities and greater heat loads. Female mice had significantly higher levels of corticosterone (2 fold) and greater levels of metabolic hormones associated with adipose tissue. Analyses of metabolic hormones and histology in both sexes suggest transient injury or stunning to the pancreas.


Descriptors :   ORGANS (ANATOMY) , wounds and injuries , HEAT STROKE , HEAT STRESS (PHYSIOLOGY) , hormones , ANTIINFLAMMATORY AGENTS , drugs , tissues (biology) , blood plasma , METABOLOMICS , adipose tissue , sex , HISTOLOGY , biological markers , CYTOKINES


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE