Accession Number : AD1045133


Title :   Immune-Stimulating Combinatorial Therapy for Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : John Hopkins University Baltimore United States


Personal Author(s) : Ivkov, Robert


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1045133.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 32


Abstract : In this project we aim to demonstrate a proof-of-concept in an animal model that combined radiation therapy and magnetic nanoparticle hyperthermia can elicit an anti-cancer immune response to inhibit progression of prostate cancer tumors. During this reporting period we 1) established a suitable tumor model and methods for inducing tumor immunologic effects with magnetic iron oxide nanoparticle (MION) hyperthermia and external beam radiation therapy; and, 2) developed methodologies that will be used to elucidate the role of key immune cell populations in tumors. Results obtained during this reporting period indicate that treatment of a model primary tumor by nanoparticle hyperthermia alone does not elicit a measurable response in a distal (untreated) tumor; whereas radiation therapy alone generated a modest response in distal tumors. Interestingly, the combination of radiation hyperthermia produced the greatest observed distal tumor growth inhibition, and was associated with significantly elevated intratumor FOXP3, a master immune regulatory protein, levels. Radiation and hyperthermia single-agent therapies were associated with FOXP3 levels similar to untreated controls. These early results are encouraging and motivate further study.


Descriptors :   Hyperthermia , RADIOTHERAPY , immunotherapy , prostate cancer , nanoparticles , t lymphocytes , cytokines , neoplasms , inhibition , proteins , cell line , probes , DOSIMETRY


Subject Categories : Medicine and Medical Research
      Radiobiology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE