Accession Number : AD1045034


Title :   Vision Restoration with a Collagen Cross-linked Boston Keratoprosthesis Unit


Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Corporate Author : Massachusetts Eye and Ear Infirmary Boston United States


Personal Author(s) : Ciolino, Joseph B ; Langone,Lisa


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1045034.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 15


Abstract : The Boston Keratoprosthesis is the most widely used keratoprosthesis worldwide and is implanted in the eyes of patients who are not candidates for a traditional corneal transplant. Unfortunately, the most common cause of keratoprosthesis failure is due to keratolysis (corneal melts), which can result in devastating sight-threatening complications and /or loss of the eye. Within the keratoprosthesis unit, corneal melts typically develop in the corneal graft that serves as a carrier for the optic. We have developed a method to reduce the incidence or potentially eliminate corneal melts by strengthening the keratoprosthesis carrier tissue by collagen-crosslinking the cornea graft ex vivo using vitamin B2 (riboflavin) and ultraviolet light. The overall objective of this study is to prevent sight-threatening keratoprosthesis corneal melts and identify an improved treatment for patients who are not candidates for traditional corneal transplants.


Descriptors :   PROSTHESES AND IMPLANTS , PROSTHESIS IMPLANTATION , Surgical transplantation , CORNEA , EYE


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE