Accession Number : AD1045034

Title :   Vision Restoration with a Collagen Cross-linked Boston Keratoprosthesis Unit

Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017

Corporate Author : Massachusetts Eye and Ear Infirmary Boston United States

Personal Author(s) : Ciolino, Joseph B ; Langone,Lisa

Full Text :

Report Date : 01 Sep 2017

Pagination or Media Count : 15

Abstract : The Boston Keratoprosthesis is the most widely used keratoprosthesis worldwide and is implanted in the eyes of patients who are not candidates for a traditional corneal transplant. Unfortunately, the most common cause of keratoprosthesis failure is due to keratolysis (corneal melts), which can result in devastating sight-threatening complications and /or loss of the eye. Within the keratoprosthesis unit, corneal melts typically develop in the corneal graft that serves as a carrier for the optic. We have developed a method to reduce the incidence or potentially eliminate corneal melts by strengthening the keratoprosthesis carrier tissue by collagen-crosslinking the cornea graft ex vivo using vitamin B2 (riboflavin) and ultraviolet light. The overall objective of this study is to prevent sight-threatening keratoprosthesis corneal melts and identify an improved treatment for patients who are not candidates for traditional corneal transplants.


Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE