Accession Number : AD1044981


Title :   Identification of Androgen Receptor-Specific Enhancer RNAs


Descriptive Note : Technical Report,15 May 2015,14 May 2017


Corporate Author : University of Mississippi Medical Center Jackson United States


Personal Author(s) : Mo, Yin-Yuan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1044981.pdf


Report Date : 01 Aug 2017


Pagination or Media Count : 9


Abstract : The major goal of this application is to determine whether prostate cancer cells express enhancer RNAs in response to androgen treatment such that these enhancer RNAs may serve as novel biomarkers for prostate cancer diagnosis and prognosis. There are two Tasks in this application. First, we will perform global run-on assay and deep sequencing to identify AR-specific enhancer RNAs. Second, we will validate them and then determine their functional significance. The success of this study may lead to novel clinical applications such as identification of biomarkers or therapeutic targets for prostate cancer, especially for castration resistant prostate cancer.


Descriptors :   biological markers , ribonucleic acids , androgens , prostate cancer , DIAGNOSIS (MEDICINE) , cancer screening , assays , cell line


Subject Categories : Medicine and Medical Research
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE