Accession Number : AD1044910


Title :   Gene-Specific Demethylation as Targeted Therapy in MDS


Descriptive Note : Technical Report,15 Jun 2016,14 Jun 2017


Corporate Author : Beth Israel Deaconess Medical Center Boston United States


Personal Author(s) : Tenen ,Daniel G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1044910.pdf


Report Date : 01 Jul 2017


Pagination or Media Count : 8


Abstract : Myelodysplastic Syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and risk of progression to Acute Myeloid Leukemia (AML) in approximately 30 percent of the cases. Aberrant DNA methylation is considered a dominant mechanism for Tumor Suppressor Genes silencing during MDS evolution to AML, but the causes leading to aberrant DNA methylation remain elusive. This proposal builds on our recent discovery of a novel class of RNAs, the DiRs or DNMT1-interacting RNAs, involved in cell type-specific DNA methylation patterns. Based on these findings, we hypothesize that DNA methylation changes can be corrected by RNAs.


Descriptors :   BLOOD DISEASES , BONE MARROW CELLS , HEMATOPOIETIC CELLS , methylation , Deoxyribonucleic acids , Rna , TRANSCRIPTION FACTORS , gene expression


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE