Accession Number : AD1044907

Title :   Vascular and Skeletal Muscle Function in Gulf War Veterans Illness

Descriptive Note : Technical Report,01 Jul 2016,30 Jun 2017

Corporate Author : Boston VA Research Institute, Inc. Boston United States

Personal Author(s) : Kinlay, Scott

Full Text :

Report Date : 01 Jul 2017

Pagination or Media Count : 13

Abstract : Gulf War Illness (GWI) is a constellation of symptoms including fatigue, musculoskeletal pain, memory loss, and mood changes reported by Gulf War Veterans shortly after their return in 1991. Approximately 40% of Gulf War Veterans (over 1/4 million Veterans) have GWI by the Center for Disease Control criteria for GWI (a recommended method for defining GWI). The underlying causes of GWI are poorly understood. The overall goal of our study is to determine if there are differences in blood vessels, skeletal muscle performance, and their controlling proteins and genes in Gulf War Veterans with and without GWI. Abnormalities in these factors may explain the symptoms of fatigue and muscle pain that are major parts of GWI. These insights could lead to new treatments for GWI as well as other illnesses with similar symptoms. Our pilot data show that we can assess blood flow to muscle, muscle strength and fatigue and examine proteins and genes from a specimen of muscle in Gulf War Veterans. We will assess if abnormalities in these factors are potential explanations for GWI. This study is seeking to enroll 70 Veterans (35 with GWI and 35 without GWI) and is currently open to enrollment.

Descriptors :   Persian Gulf Syndrome , veterans (military personnel) , PATHOPHYSIOLOGY , SKELETAL MUSCLE , blood vessels , proteins , genes , RNA SEQUENCE ANALYSIS , assays , STRESS TESTS , biopsy , EXERCISE (PHYSIOLOGY) , Histopathology , Electron Microscopy , gene expression , mitochondria , MICROARRAY ANALYSIS

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE