Accession Number : AD1044905


Title :   Targeting Discoidin Domain Receptors in Prostate Cancer


Descriptive Note : Technical Report,01 Aug 2016,31 Jul 2017


Corporate Author : Wayne State University Detroit United States


Personal Author(s) : Fridman, Rafael


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1044905.pdf


Report Date : 01 Aug 2017


Pagination or Media Count : 14


Abstract : We report the progress of our studies focusing on the Discoidin Domain Receptors (DDRs), a set of kinase receptors that signal in response to collagen in prostate cancer. The projects goal is to define the expression and therapeutic potential of DDRs in prostate cancer. During the second funding period, we concluded the immunohistochemical study of DDR1 expression in a 200 case Grade/Stage tissue microarray (TMA) using a highly specific antibody. These studies described the localization of DDR1 in normal vs. tumor tissues and the association between staining intensity and Gleason score. We found that DDR1 expression may be an early indicator of PCa development. DDR1 is over-expressed in tumor tissues among the low Gleason score patients but not in the high Gleason score patients. We continued the studies to test a highly specific DDR1 blocking antibody (Ab) in intraosseous growth of human PC3 prostate cancer cells.


Descriptors :   Prostate cancer , bone , metastasis , kinases , IMMUNOCHEMISTRY , antibodies , neoplasms , bioluminescence , tyrosine , cell line


Subject Categories : Medicine and Medical Research
      Biochemistry
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE