Accession Number : AD1044401


Title :   Comprehensive Genetic Characterization of Intraprostatic Chronic Inflammation and Prostate Cancer in African American Men


Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Corporate Author : Tulane University New Orleans United States


Personal Author(s) : Ledet, Elisa M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1044401.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 17


Abstract : African-Americans (AA) have a higher incidence of prostate cancer (PCa) and higher mortality. Stromal and epithelial inflammatory processes have a fundamental role in carcinogenesis and may predict PCa clinical progression. Discovery of novel variants as well as re-discovery of known variants deliver new opportunities for therapeutic advances such as new drug targets and personalized therapy. We hypothesize next-generation whole genome sequencing, paired with new methodologies of intratumoral phylogenetic analyses, will yield pivotal information in elucidating the key genes involved evolution of PCa from precursor inflammatory lesions in AA men. During this research period, extensive translational research training has been completed including both clinical training as well as training in bioinformatics. The most significant outcome of the present study has been the assemblage of a robust database of clinical annotation and follow-up for early stage prostate cancer patients treated at Tulane University Medical Center. This database combined with both clinical and experimental genetic data produced by this study may empower patients and doctors to make personalized treatment decisions and ultimately improve treatment outcomes. Similarly, as product of training, research database and ongoing genetic analyses, the PI has had the opportunity to collaborate on numerous publications, conference presentations, and grant opportunities.


Descriptors :   prostate cancer , AFRICAN AMERICANS , INFLAMMATION , GENETICS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE