Accession Number : AD1043771


Title :   Development of Novel Local Analgesics for Management of Acute Tissue Injury Pain


Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Corporate Author : Childrens Hospital Corporation Boston United States


Personal Author(s) : Woolf, Clifford ; Andrews,Nick


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1043771.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 22


Abstract : The goal of our project is to develop novel, non-addictive, treatments for acute soft tissue and skeletal injuries, such as seen in battlefield trauma, without the problems associated with opioid drugs. Our strategy is to target the delivery of small, membrane impermeant sodium channel blockers through large pore TRP channels, such as TRPV1. These channels act as the innate trigger of nociceptive and inflammatory pain, and are therefore open at the site of acute injury and during the subsequent phases of inflammatory pain that follow. We initiated a series of in vitro drug screens to identify new chemical entities that show promise as potential clinical candidates for non-opioid treatment of pain related to battlefield injury. Of the 31 compounds screened during the review period, we have identified 5 that show superior properties to our tool compound, QX-314.


Descriptors :   Analgesics , PAIN MANAGEMENT , WOUNDS AND INJURIES , TRAUMA , morphine , PAIN


Subject Categories : Pharmacology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE