Accession Number : AD1043447


Title :   A Multidisciplinary Approach to Study the Role of the Gut Microbiome in Relapsing and Progressive MS


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : University of California San Francisco United States


Personal Author(s) : Cree, Bruce C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1043447.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 9


Abstract : The project is both scientifically and financially on track. In the last year we have concentrated in recruiting the subjects to analyze during the third and final year of this project. Recruitment of RRMS and control subjects is close to target, while recruitment of PPMS subjects is proceeding at a slower pace, as anticipated. We plan to stop recruitment in February 2018, and proceed to process samples for sequencing and genotyping in order to complete the project in September of 2018.On the experimental side, a group of 24 germ-free mice was colonized with human microbiota and EAE was induced. We expect results of this experiment by November 2017. A second experiment to replicate our results will follow shortly.


Descriptors :   multiple sclerosis , BIOMEDICAL INFORMATION SYSTEMS , Immunology


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE