Accession Number : AD1043281


Title :   Synergistic Interactions of Neuroprotective and Neurotrophic Factors Against Sleep Deprivation


Descriptive Note : Technical Report,01 May 2013,30 Sep 2016


Corporate Author : 711 HPW/RHDJ Wright-Patterson AFB United States


Personal Author(s) : Soto,Armando ; Chan,Victor T ; DelRaso,Nicholas J ; Grant,Levaugh C ; Walters,Amy D ; Dixon,David A ; Braddock,Amber ; Soto,Jonathon ; Reo,Nicholas V ; Capati,Renell H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1043281.pdf


Report Date : 01 Mar 2017


Pagination or Media Count : 59


Abstract : Sleep deprivation is one of the most common stressors that Airmen face during military missions. Exposure to this stressor will diminish performance increase the risk of make mistakes during critical assignments. Previous investigations have suggested that damaging brain effect of sleep deprivation may be caused by accumulation of reactive oxidant species, triggered by the decrease in the antioxidant defense and malfunction of the endoplasm reticulum (ER) molecular chaperones, and consequently, causing an increase in neuronal cell death.


Descriptors :   Sleep deprivation , FLIGHT CREWS , brain , STRESS PHYSIOLOGY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE