Accession Number : AD1043110


Title :   Use of Topical PC-NSAIDs to Treat Burn Injury and Pain


Descriptive Note : Technical Report,05 Jul 2014,04 Jul 2017


Corporate Author : University of Texas Health Science Center at Houston Houston United States


Personal Author(s) : Lichtenberger, Lenard M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1043110.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 17


Abstract : Studies have shown that the rat dorsal skin and hind limb burn injury models of 2nd degree burns are appropriate for testing the analgesic and healing rate efficacy of test drugs. These models were used to test Ibuprofen (Ibu), Ibuprofen associated with phosphatidylcholine (Ibu-PC), Indomethacin (Indo), and Indo-PC. The experimental drug Indo-PC showed analgesic and anti-inflammatory efficacy over Indo alone or the Ibu drugs, notably when administered parenterally without notable side-effects. These studies support a rationale for continued development of parenteral Indo-PC for treatment of 2nd degree burn wounds.


Descriptors :   burns , ANTIINFLAMMATORY AGENTS , drugs , pain , inflammation , toxicity , models


Subject Categories : Pharmacology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE