Accession Number : AD1042924


Title :   Androgen Receptor Splice Variants and Resistance to Taxane Chemotherapy


Descriptive Note : Technical Report,29 Sep 2016,28 Sep 2017


Corporate Author : Tulane University New Orleans United States


Personal Author(s) : Zhang, Haitao


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1042924.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 12


Abstract : During this reporting period, we have obtained approval for a no-cost extension of this award and change of research focus in the final year. This report will summarize the research activities and achievements up to date, organized based on the revised Statement of Work. In summary, we have 1) Identified two regions in the AR LBD that confer the microtubule-binding activity; 2) Further characterized the functional significance of the AR-microtubule interaction and provided compelling evidence to suggest that the microtubules play an important role in controlling the intracellular localization and activity of AR; 3) Provided a fundamental understanding of the constitutive nuclear localization and transcriptional activities of AR-V7 and ARv567es; and 4) Developed and validated a whole-blood assay for the detection of both AR-V7 and ARv567es.


Descriptors :   prostate cancer , chemotherapy , therapeutics , resistance , cost effectiveness


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE