Accession Number : AD1042684


Title :   FLT-PET/CT as a Biomarker of Therapeutic Response in Pemetrexed Therapy for Non-Small Cell Lung Cancer


Descriptive Note : Technical Report,30 Sep 2014,29 Sep 2016


Corporate Author : University of Pennsylvania Perelman School of Medicine Philadelphia United States


Personal Author(s) : Katz, Sharyn I


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1042684.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 57


Abstract : Pemetrexed(PEM), a standard therapy for non-squamous non-small cell lung cancer (NSCLC), inhibits the de novo thymidine pathway, resulting in a transient burst of metabolism through the salvage pathway, an effect detected as a flare of activity by 18F-thymidine (FLT)-PET. FLT is a reliable biomarker of proliferation, and post-therapeutic changes in tumor FLT avidity predicts therapeutic response in a range of malignancies. However, FLT as a measure of therapeutic response in NSCLC is not well studied. Our overarching hypothesis is that FLT-PET will allow early assessment of therapeutic response in NSCLC with the following specific aims:Specific Aim 1: To determine the optimal timing to measure FLT flare, an imaging biomarker of successful PEM-induced TS inhibition in a NSCLC preclinical model. Specific Aim 2: To conduct a proof-of-concept clinical study of FLT flare and FLT-measured changes in tumor proliferation at 2 weeks of therapy as predictors of NSCLC response to PEM. During the research period, we have determined that the optimal time to observe FLT flare in vivo is at 2 hrs following therapy start. This data has been translated to an open clinical trial of FLT-PET as a biomarker of therapy response in NSCLC proposed in Specific Aim #2.


Descriptors :   therapeutics , xray computed tomography , imaging techniques , culture techniques , antibacterial agents , cell line , chemotherapy , clinical trials , neoplasms , drug therapy , positron emission tomography , cell physiological processes , health services , GENETIC MARKERS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE