Accession Number : AD1042642

Title :   Contribution of p75NTR to Schwannoma Growth and Therapeutic Responses

Descriptive Note : Technical Report,01 May 2016,30 Apr 2017

Corporate Author : University of Iowa Iowa City United States

Personal Author(s) : Hansen,Marlan R ; Ahmad,Iram ; Clark,J Jason ; Rasmussen,Jed ; Yates,Charles

Full Text :

Report Date : 01 May 2017

Pagination or Media Count : 40

Abstract : We find that the NF2 gene product, merlin, regulates p75NTR expression levels and signaling. This depends on the phosphorylation state of merlin. We also find that activation of p75NTR fails to induce apoptosis in SCs and schwannoma cells that lack functional merlin expression, in contrast to normal SCs. Further, activation of p75NTR in human VS cells protects the cells from some forms of cell death.

Descriptors :   peripheral nervous system , cell physiological processes , culture techniques , cell line , ganglia , proteins , stress (physiology) , neoplasms , hearing disorders , chemical reactions , brain , skin diseases , sensory ganglia , ribonucleic acids , therapeutics , KINASES , radiation

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE