Accession Number : AD1042642


Title :   Contribution of p75NTR to Schwannoma Growth and Therapeutic Responses


Descriptive Note : Technical Report,01 May 2016,30 Apr 2017


Corporate Author : University of Iowa Iowa City United States


Personal Author(s) : Hansen,Marlan R ; Ahmad,Iram ; Clark,J Jason ; Rasmussen,Jed ; Yates,Charles


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1042642.pdf


Report Date : 01 May 2017


Pagination or Media Count : 40


Abstract : We find that the NF2 gene product, merlin, regulates p75NTR expression levels and signaling. This depends on the phosphorylation state of merlin. We also find that activation of p75NTR fails to induce apoptosis in SCs and schwannoma cells that lack functional merlin expression, in contrast to normal SCs. Further, activation of p75NTR in human VS cells protects the cells from some forms of cell death.


Descriptors :   peripheral nervous system , cell physiological processes , culture techniques , cell line , ganglia , proteins , stress (physiology) , neoplasms , hearing disorders , chemical reactions , brain , skin diseases , sensory ganglia , ribonucleic acids , therapeutics , KINASES , radiation


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE