Accession Number : AD1042324


Title :   Activation of mTor Signaling by Gene Transduction to Induce Axon Regeneration in the Central Nervous System Following Neural Injury


Descriptive Note : Technical Report,01 Feb 2016,31 Jul 2017


Corporate Author : Columbia University New York United States


Personal Author(s) : Burke, Robert E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1042324.pdf


Report Date : 01 Aug 2017


Pagination or Media Count : 14


Abstract : A long-standing belief about injuries and diseases of the brain and spinal cord has been that once axons are destroyed, they will not re-grow. This belief is now being challenged. As the brain matures, the genetic programs that control axon growth during development are silenced. Recent evidence shows that reactivation of these programs in the adult successfully induces axon growth. We have shown that reactivation of Akt/mTORC1 signaling, by use of AAV vector transfer, induces regrowth of dopaminergic axons at 3 to 6 weeks after destruction by a neurotoxin. However, this approach cannot be used in humans because Akt/mTORC1 signaling is oncogenic. The goal of this proposal is to refine this approach to achieve restorative effects in the absence of adverse effects.


Descriptors :   central nervous system , therapeutics , AXONS , proteins , Regeneration (Physiology)


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE