Accession Number : AD1041628


Title :   Safety Parameter Considerations of Anodal Transcranial Direct Current Stimulation in Rats


Descriptive Note : Technical Report,01 Oct 2015,01 Sep 2017


Corporate Author : Infoscitex Corporation Dayton United States


Personal Author(s) : McKinley,R A ; Jankord,Ryan ; Jackson,Mark P ; Truong,Dennis ; Bikson,Marom ; Brownlow,Milene L ; Wagner,Jessica A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1041628.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 28


Abstract : A commonly referenced transcranial Direct Current Stimulation (tDCS) safety threshold derives from tDCS lesion studies in the rat and relies on electrode current density (and related electrode charge density) to support clinical guidelines. Concerns about the role of polarity (e.g., anodal tDCS), sub-lesion threshold injury (e.g., neuroinflammatory processes), and role of electrode montage across rodent and human studies support further investigation into animal models of tDCS safety.


Descriptors :   direct current , current density , brain , electrodes , statistical analysis , computational modeling


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE