Accession Number : AD1041558


Title :   Relevancy of Serum Calcium in Predicting Blood Product Transfusion in Trauma


Descriptive Note : Technical Report,01 Sep 2014,31 Mar 2016


Corporate Author : USAF School of Aerospace Medicine Wright-Patterson AFB United States


Personal Author(s) : Bryan,Rance ; Lindsay,Kathryn ; Putty,Bradley ; Grimm,Jason ; Freeman,Carl


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1041558.pdf


Report Date : 10 Aug 2017


Pagination or Media Count : 11


Abstract : Uncontrolled hemorrhage is the leading cause of preventable mortality in trauma. Rapid identification of patients requiring blood transfusion during assessment and resuscitation is necessary for mortality reduction. Most pre-hospital or field medical criteria used to predict blood product needs in trauma patients rely on a combination of physiological, anatomic, and mechanism-of-injury components. Calcium (Ca) activates protein kinase C and is required for coagulation factors to bind properly in the clotting cascade. Ca has presented a novel laboratory test to predict early blood transfusion. The purpose of this study was to identify a relationship between serum Ca levels and the need for early transfusion. In this retrospective analysis, serum Ca 7.9 mg/dL was strongly associated with the need for blood product transfusion, as well as transfusion of more than four units within 4 hours, even after controlling for other clinical variables. This effect was age specific for the subject group aged 40 years and below. Patients with normal blood pressure could give medical teams a false sense of patient stability. Younger patients have a compensating capacity with blood loss and will not show signs of shock until they have exhausted this mechanism.


Descriptors :   health services , blood transfusions , cardiovascular physiological phenomena , blood cells , blood banks , casualties , hemorrhage , physiological monitoring , RESUSCITATION , trauma , HYPOTENSION , anemias , calcium , patients , patient care


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE