Accession Number : AD1040943


Title :   Technique Development Results for the Study of a Novel Dexamethasone Impregnated Bandage Contact Lens in a Rabbit Model After Photorefractive Keratectomy


Descriptive Note : Conference Paper


Corporate Author : 59th Medical Wing San Antonio United States


Personal Author(s) : Soeken,Timothy A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1040943.pdf


Report Date : 22 Oct 2017


Pagination or Media Count : 2


Abstract : Introduction: Many conditions can lead to ophthalmic inflammation, which can become painful and blinding. Steroid eye drops are the most common treatment and compliance is often acomplicating issue. In attempts to alleviate compliance errors, experimental contact lenses impregnated with steroids are now being produced. This study is investigating an experimental dexarnethasone-eluting contact lens.Methods: Thirty-five New Zealand White rabbits were approved for use in the technique development stage and in four different study arms. The technique development stage had different refractive surgery procedures, tarsorrhaphy configurations, and nictitating membranecon figurations to determine the best surgical combination for study results. The first study arm included the experimental contact lens replaced weekly, a second arm with a bandage contact lens replaced weekly, a third arm with a bandage contact lens only the first week, and a fourth arm with no bandage contact lens at any point. The non-experimental contact lens arms received dexamethasone drops. The left eye served as control.


Descriptors :   medical research , eye , surgery , ophthalmology , animal experimentation , therapy , inflammation


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE