Accession Number : AD1039692


Title :   Pupillometry and Saccades as Objective mTBI Biomark


Descriptive Note : Technical Report,30 Sep 2014,29 Mar 2017


Corporate Author : The Geneva Foundation TACOMA United States


Personal Author(s) : Capo-Aponte,Jose E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1039692.pdf


Report Date : 01 Jun 2017


Pagination or Media Count : 77


Abstract : The objective of the study is to validate pupillary light reflex (PLR), saccadic and convergence eye movements as objective biomarkers for the identification of Warfighters with acute mild traumatic brain injury (mTBI) using commercial-off-the-shelf (COTS) instruments: infrared pupillometers, King-Devick (KD) test and near point of convergence (NPC) rule,respectively. Hundred mTBI and 100 age-matched non-TBI (controls) military personnel were recruited from the patient population at Womack Army Medical Center (WAMC). This study was designed to determine within each group the effectiveness of these tests, individually and/orin combination, to correctly identify mTBI in agreement with the mTBI diagnosis made by the WAMC Department of Brain Injury Medicine. Results showed that three of the eight PLR parameters are statistically different between the groups: average constriction velocity, average dilation velocity, and 75% dilation recovery time. In addition, the KD test, NPCrule, and the CISS survey showed sensitivity in identifying military personnel with mTBI.


Descriptors :   brain injuries , biological markers , military medicine , traumatic stress disorder , military personnel , regression analysis , anxiety disorders , signs and symptoms , nervous system , eye movements


Subject Categories : Medicine and Medical Research
      Military Forces and Organizations


Distribution Statement : APPROVED FOR PUBLIC RELEASE