Accession Number : AD1039600


Title :   Marrow Derived Antibody Library for the Treatment of Neuroblastoma


Descriptive Note : Technical Report,01 Sep 2012,30 Sep 2015


Corporate Author : SPECTRUM HEALTH SYSTEM GRAND RAPIDS United States


Personal Author(s) : Saulnier Sholler,Giselle


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1039600.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 16


Abstract : Neuroblastoma (NB) is the most common solid tumor in children, which accounts for 15% of all pediatric cancer deaths in the US. New therapeutic antibodies to treat NB are urgently needed to improve survival. The purpose of this project is to produce patient-specific therapeutic antibodies to treat neuroblastoma. The goal is to develop new methods and strategies to capture the auto-immune response reaction in neuroblastoma patients using phage display and B cell hybridoma technologies. The scope of this project is to use NB patient-derived materials to create NB cell lines, xenograft models, NB specific phage display libraries and to identify and amplify functional anti-NB specific antibodies for future therapeutic intent.


Descriptors :   biological staining and labeling , bacterial infections , histological techniques , confocal microscopy , cell membrane , amino acids , therapeutics , surgical procedures , neuroblastoma , neoplasms , antibodies , lymphatic system , bone marrow , ANTIBODIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE