Accession Number : AD1039581


Title :   Poloamer 188 as an Adjunct in Prolonged Hypotensive Resucitation


Descriptive Note : Technical Report,01 Jul 2006,30 Jun 2007


Corporate Author : The University of Texas Health Science Center at Houston Houston United States


Personal Author(s) : Hunter,Robert ; Moore,Frederick ; Gonzalez,Ernest ; Zhang,Rongzhen


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1039581.pdf


Report Date : 01 Jul 2017


Pagination or Media Count : 7


Abstract : Despite tremendous efforts, exsanguinations remains a leading cause of deaths (approximately 40 %) in both civilian and military trauma. A subset of injured soldiers develop decompensated shock that requires early interventions if they are to survive. This project is testing the ability of a new drug, purified poloxamer 188 (P188), to increase survival and reduce inflammation and organ injury resulting from prolonged periods of hypotensive resuscitation in a model specified by the ARMY. The results are strongly positive. Addition of P188 to standard therapy with Hextend significantly improved survival (p=0.002)and reduced fluid requirements (p=0.0002) in rats subjected to prolonged hypotensive resuscitation. These studies are being followed up with studies with more complex injuries and with uncontrolled hemorrhage in rats, rabbits and pigs.


Descriptors :   drug therapy , hypotension , inflammation , survivability , cardiovascular physiological phenomena , hemorrhagic shock , resuscitation , symptoms and general pathology , pathologic processes , hypovolemia , infusions , heart rate , laboratory animals , copolymers


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE